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Toronto
Institute of
Pharmaceutical Technology
55 Town Centre Crt. Suite
800
Toronto, Ontario
M1P 4X4, CANADA
Tel: (416) 296-8860
Fax: (416) 296-7077
Email: info@tipt.com |
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Professor MacGregor teaches advanced courses in drug delivery, pharmacokinetics and formulation technology to postgraduate students in the Research & Development program. He is also an external examiner and supervisor of doctorate students completing PhD programs in pharmaceutical science.
His main research focus is in the design, development and clinical testing of pharmaceutical and bio-pharmaceutical products aimed at targeting invasive tumours, diabetes and deep tissue infections.
Selected Recent Publications and Patents:
Hydrodynamic Drug Delivery Systems for Controlled Delivery of Agent : Alexander MacGregor 2001
The present invention provides a hydrostatic delivery system including a hydrostatic couple and an agent of interest. The hydrostatic couple includes at least one hydrodynamic fluid-imbibing polymer, and at least one hydrostatic pressure modulating agent. This delivery system has the ability to control the release of one or more agents of interest within a fluid environment following zero-order kinetics.
Read more: http://www.faqs.org/patents/app/20080317847#ixzz0gUjohdQ1
Reverse-Micellar Drug Delivery System for Controlled Transportation and Enhanced Absorption of Agent: 2005 Alexander MacGregor.
The present invention provides a reverse-micellar delivery system for enhanced absorption of an agent of interest across biological membranes such as the gastro-intestinal tract of mammals.
Read more: http://www.freepatentsonline.com/EP1453481.html
Method of Treating Dysglycemia and Glucose Excursions: Alexander MacGregor 2009
The present application relates to pharmaceutical compositions for reducing glucose excursions in a normal subject or a subject having an insulin-related disorder or dysglycemia. The pharmaceutical composition contains one or more active agent-containing layers, which each contain a dry blended mixture including a therapeutically effective amount of a polar ionizable insulin-sensitizing oral hypoglycemic agent or a pharmaceutically acceptable salt thereof, and an amphipathic compound in monomeric ……
Read more: http://brevets-patents.ic.gc.ca/opic-cipo/cpd/eng/patent/2638240/summary.html?query=macgregor&start=1&num=50&type=basic_search#View_Abstract
Wenming Zeng, Frank Martinuzzi and Alexander MacGregor ; Development and application of a novel UV
method for the analysis of ascorbic acid ; Journal of Pharmaceutical and Biomedical Analysis
Volume 36, Issue 5, 4 January 2005, Pages 1107-1111
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Tanush Kadria became a member of faculty in April of 2006, bringing his expertise in formulation and pharmacokinetics to his role as an Associate Professor and Formulation Scientist at TIPT. His primary area of focus is pharmaceutical technology and pharmacokinetics. Tanush provides valuable hands-on training and supervise research & development student practical projects. Tanush is also actively involved in research at TIPT in the area of solid-dosage formulation and advanced proof-of-concept experiments.
Professor Kadria’s background is in industrial chemistry, pharmacology and pharmacokinetics. In addition to his post-graduate diploma in pharmaceutical Research &Development, he hold multiple-disciplined degrees in Industrial Chemistry (B.Sc.) and Pharmacy (B.Pharm) both from the University of Tirana.
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Dr. Tarek Zaid joined the faculty of TIPT in July 2005, bringing with him several years’ worth of experience and education in the chemical sciences to his role as a lecturer. He is an Associate Professor and primarily instructs students in the Research & Developments and Regulatory Affairs program where he applies his expertise in pharmaceutical technology, medical biochemistry and chemical pathology. He also supervises students during their projects and practical workshops.
Dr. Zaid is a chartered chemist and is also involved in clinical research at TIPT as a Clinical Research Associate, monitoring the clinical studies that are conducted. His extensive educational background includes a post-graduate diploma in pharmaceutical Research & Development from Toronto Institute of Pharmaceutical Technology (TIPT), a PhD (Medical Biochemistry) and an M.Sc. (Biochemistry and Chemical Pathology) from the Faculty of Medicine, Cairo University, a post-graduate Diploma (Microbiology) and a B.Sc. (Biochemistry and Chemistry) from the Faculty of Science, Ein Shames University.
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Dr. Job Kiara joined the faculty of TIPT in July 2005, bringing with him several years’ worth of experience and education in the bio-chemical and pharmaceutical sciences to his role as a lecturer. He is an Associate Professor and primarily instructs students in the Regulatory Affairs and Research & Developments program. He also supervises students during their projects and practical workshops.
Dr. Kiara is also involved in clinical research at TIPT as a Clinical Research Coordinator, monitoring Phase I and Phase II clinical studies that are conducted at the Institute. His extensive educational background includes a post-graduate diploma in pharmaceutical Research & Development from Toronto Institute of Pharmaceutical Technology (TIPT), a post-graduate certificate in Clinical Research from Mitchner Institute for Applied Health Sciences, and a PhD (Biochemistry) from the Faculty of Biochemistry, Nairobi University
Research Highlights:
• David Ma, Job Kiaira, Natalie Faubert(2005),Controlled Release of Caffeine from a Hydroxyethylcellulose
Matrix (Internal Report).
• David Ma, Job Kiaira, Natalie Faubert, Russell Williams(2005).Scale-up Process for Immediate Release
Diphenhydramine Hydrochloride Tablets(Internal Report).
• David Ma, Natalie Faubert, Russell Williams, Job Kiaira (2005).A Comparison of tablet parameters for
caffeine tablet formulations
• T.N. Mungai, J.K. Kiaira, V.N. Konji (1999) Carbohydrate metabolism and the fate of reducing
equivalents in the in vitro propagated Theileria parva schizonts. Veterinary Journal 158. 221-227
• H.V. Obungu, J.K. Kiaira, R.M. Njogu and N.K. Olembo (1999). Catabolism of proline by procyclic culture
forms of Trypanosoma congolense. Comparative Biochemistry and Physiology Part B 123:59-65
• Obungu, H.V., Kiaira, J.K Olembo, N.K and Njogu, R.M (1999) Pathways of glucose catabolism procyclic
Trypanosoma congolense. Indian J. Biochemistry and Biophysics 36: 305-311 .
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William (Bill) Hodgson initially became a member of the TIPT faculty in 1997 and in 2003 became a full-time Associate Professor. He specializes in regulatory compliance and aseptic technology. As an instructor he teaches pharmaceutical GMP, Microbiology, Health and Safety and Statistics. In addition, he has also conducted GMP training for professionals from various pharmaceutical companies.
Before joining TIPT, Professor Hodgson gained several years of experience and education as QA/QC analyst and Quality Services manager in a large manufacturing companies in Canada and through his studies at the University of Guelph, where he attained B.Sc. in Microbiology, the Siebel Institute of Brewing Technology (with a Diploma of Brewing Technology) and at TIPT, where he successfully earned a postgraduate diploma in Quality Assurance and Quality Control.
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Frank Martinuzzi joined TIPT in June 1999 as a Research and Development Associate and Project Coordinator. He became a member of faculty and General Manager of Operations and Laboratory in 2002. His role in management includes overseeing internal operations and coordination of on-going domestic and international pharmaceutical projects. Mr. Martinuzzi is also clinical monitor in the various clinical research studies at TIPT. As a member of faculty, he provides faculty affairs management and teaches courses in the Regulatory Affairs and Research & Development programs where he applies his expertise in research and development to the benefit of students in the core and advanced modules.
In addition to a postgraduate diploma in pharmaceutical research and development from the Toronto Institute of Pharmaceutical Technology (TIPT), he also holds a B.Sc. (Physiology Specialist) from the University of Toronto.
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Dr. Ramjeet Persaud Harinarain is an Associate Professor at the Toronto Institute of Pharmaceutical Technology and has been a part of the faculty since 2002. In addition to his post-graduate diploma in Pharmaceutical Research and Development, he also holds a PhD in Agriculture Science specializing in Plant Tissue Culture. With additional studies completed in Project Management at Humber College and a Teacher/Trainer of Adults from Centennial College, Dr. Harinarain brings a wealth of knowledge and experience to the students of the R&D, QA, QC, and RA programmes at TIPT.
In addition to his work with TIPT students, Dr. Harinarain is also involved in Generic Drug Product Development and is currently a part-time M.Ed. student in the Faculty of Education at York University. His research interests in post-secondary education include Postmodernists Philosophy, Pedagogical Practices, Curriculum Orientations, Vocational and Adult Education.
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Dr. Saeed joined the TIPT faculty as an Associate Professor in 2009. In addition to his role as an lecturer, he is also involved in the coordination of quality assurance activities in the TIPT research Bio-Laboratory, on-site Plant and Clinic. An expert in the areas of pharmaceutical physical and analytical chemistry, he has particular expertise and skill in the areas of bulk material and finished products testing.
Professor Saeed obtained his Ph.D in Polymer Science from Case Western Reserve University (USA) and a Masters in Physical Chemistry from the University of Peshawar (Pakistan). He also has post-graduate industrial training from TIPT with a pharmaceutical research and development diploma.
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Mohammed Zamiruddin joined TIPT in October of 2002 after completing a three month internship specializing in Pharmaceutical Research and Development. As an active faculty member of TIPT, he teaches classes in research and development, quality assurance, and quality control. In addition to his role as an instructor, Professor Zamiruddin also works on various corporate research projects in areas of drug discovery, advanced-formulation development and bio-analysis.
Professor Zamiruddin’s areas of expertise is completed with over 15 years industry experience in drug stability, synthetic and analytical chemistry. A graduate of TIPT with a post-graduate diploma in Research and Development, Professor Zamiruddin also holds a M.Sc. in Organic Chemistry from the University of Chittagong, India.
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Dr. Sandra Tre-Bolou joined the faculty of TIPT in January 2010 after completing her doctorate research project under the supervision of Professor Alexander MacGregor. Dr. Tre-Bolo is an Associate Professor and primarily instructs students in the Research & Developments and Regulatory Affairs program where she applies her expertise in pharmaceutical technology and physical pharmaceutics.
Dr. Tre-Bolou obtained a doctor of pharmacy degree (PharmD) from University of Cocody- Abidjan, Cote d’Ivoire , a Master of Science degree (M.Sc.) in pharamecutical science from Long Island University, Brooklyn, New York and is currently a PhD. Candidate in pharmaceutics
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Naglaa is an Associate Professor and joined TIPT’s faculty in January of 2001 after 12 years of experience as a medical practitioner and regulatory compliance in pharmaceutical Industry. Her primary area of interest is compression science in pharmaceutical manufacturing technology and she is currently involved in the instruction of Manufacturing Technology students at TIPT, including the supervision of their practical projects.
Naglaa holds a B.Sc degree in Science and a B.Sc degree in medical sciences from Ain Shams University in Egypt as well as a diploma in Pharmaceutical Manufacturing Technology from TIPT.
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Professor Persaud is an Associate Professor and Academic Registrar at TIPT. He joined TIPT 1997. With his deep interest and expertise in regulatory compliance, students in all TIPT programmes are able to benefit from his knowledge and expertise.
In his role as Registrar at TIPT, he also oversees the administration of exams, administration of the exam marks data base and ensures the timely posting of student marks. He is also involved in the preparation of diploma and transcript information for TIPT graduates.
Professor Persaud is also involved in corporate training of pharmaceutical industry professionals in areas of regulatory compliance.
Previous to joining the Pharmaceutical Industry Professor Persaud has 15 years of experience in animal nutrition/research and management. He holds a B.Sc degree, an Advanced Diploma in Business Administration (England), a Diploma in Dairy Husbandry and Milk Processing (Netherlands) and a post-graduate Diploma in Pharmaceutical Quality Assurance and Quality Control. He also holds the pharmaceutical professional RAC accreditation from the Regulatory Affairs Professionals Society (RAPS).
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Trang Do has been apart of the faculty team here at TIPT since 2006. While contributing actively to the QA, QC, R&D, and particularly RA programmes, her primary involvement is in the planning, executing and monitoring of clinical trials, in addition to coordinating of regulatory submissions in her role as the Regulatory Affairs Associate and Clinical Research Coordinator.
Prior to joining TIPT, Ms. Do had spent several years in the healthcare industry. Appropriately, she ensures students are able to benefit from her expertise in clinical studies and regulatory affairs. Her relevant education includes an Hons. B.Sc. (Molecular Biology and Biotechnology Specialization), a Post-Graduate Dip. in Pharmaceutical Research and Development, and Project Management Certified. At the present, her research focuses on effective clinical studies management and patient compliance practices.
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Jamie is a Research & Development Associate and became a TIPT faculty member in March of 2007. In her current capacity as an instructor, she teaches several different classes at TIPT, including classes in the R&D, MT, QA and QC departments. In addition to her busy teaching role, she is also a member of the Product Development team at TIPT and works on pharmaceutical research and development on a regular basis.
With a keen interest in pharmaceutical R&D, Lugtu-Pe’s students benefit from her expertise in various areas, particularly her knowledge of the development of pharmaceutical prototypes for early-stage development. She is also interested in coatings for modified release dosage forms, a field she is currently investigating as part of her in-process M.Sc. (Pharmaceutical Sciences) at the University of Toronto. In addition to her post-graduate diploma in Pharmaceutical Research and Development from TIPT, She holds an Hons. B.Sc. (Physiology, Psychology and Spanish) from the University of Toronto.
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Galina joined TIPT in 1996 and became an Associate Professor in the QA faculty. In her role as faculty she lectures students in Pharmaceutical Analytical Chemistry and oversees laboratory courses including HPLC and other instrumental analysis. Galina supervises student research projects related to development and validation of Analytical Methods.
Professor Leltchuk has several years of experience in Analytical chemistry, Pharmaceutical quality control, Chemistry and technology of bioactive compounds. She holds a Post-graduate Quality Control Diploma from TIPT as well as one from the Institute of Patent and Technical Information, in Russia.
Galina holds a M.Sc. in Chemistry and Technology of bioactive compounds from the Moscow M.V. Lomonosov Institute (University) of Fine Chemical Technology, Russia in addition to the College Diploma (Analytical Chemistry) from the Industrial Technical School, Russia.
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Chen Si joined the faculty of TIPT in March 2010 as a Teaching Assistant and Intern after completing his postgraduate diploma program in Pharmaceutical Research & Development from the Toronto Institute of Pharmaceutical Technology. Mr. Si primarily instructs students in the Manufacturing Technology and Research & Development programs.
Mr. Si obtained his master degree (M.Sc.) in chemistry from University of British Columbia, Canada and a postgraduate diploma from TIPT
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Dr. Linh Bao Ho joined the faculty of TIPT in March 2010 as a Teaching Assistant and Research Intern after completing her postgraduate diploma program in Pharmaceutical Research & Development from the Toronto Institute of Pharmaceutical Technology. Dr. Bao primarily instructs students in the Manufacturing Technology and Research & Development programs.
Dr. Bao obtained her doctorate (PhD) in polymer chemistry from Laval University, Quebec Canada and postgraduate diploma in Pharmaceutical R&D from TIPT
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The Toronto
Institute of Pharmaceutical Technology (TIPT®) as a pioneering Institute for practical education and training in industrial
pharmaceutical science has a tradition of excellence in pharmaceutical research, with emphasis on technology-enabling practical
projects, which characterizes our identity as much as our teaching expertise.
Our research emphasis is on advancing technological capabilities and understanding of pharmaceutical processes and drug delivery
systems for industrial applications to products of medicine and health care. There are four main divisions within our research
& development department:
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Biopharmaceutics
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Our research activities in Biopharmaceutics focuses on drug pharmacokinetics, in-vivo/in-vitro relationships and the use of Design-of- Experiments (DOE) to predict and interpret drug absorption and pharmacodynamics. Current research examines ways to translate PK-PD elucidations of Class II and Class III biopharmaceutical compounds into new therapeutic benefits. [more...] |
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Formulation Sciences
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Our research activities focus on novel science and technologies to develop and understand dosage forms with scientific precision and performance predictability. Current research in formulation science includes the deployment of experimental designs (factorial and neural networks) in pre-formulation and formulation development. [more...] |
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Manufacturing Technology
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Our research activities focus on the sciences and technologies used to develop manufacturing processes as well as manufacturing scale-up models for the final dosage form of medicines [more...] |
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Drug Delivery
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Our research in drug delivery emphasizes the development of controlled oral drug delivery systems with potential benefits of patient compliance and reduced intra-subject variability. Current research examines ways of adaptive and extended release oral drug delivery systems for predictive release and absorption of therapeutic compounds. [more...] |
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